Big and medium cities that I have been to:
(just off the top of my head)
Tampa
Saint Petersburg
Jacksonville
Orlando
Tallahassee
Pensacola
Miami
Ft Lauderdale
Daytona
Sarasota
Key West
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Atlanta
Savanna Ga
Chicago
Waukegan Wis
NY City
Memphis
Knoxville
Asheville NC
Portland Maine
Portland Ore
Mazola Mont
Seattle
San Francisco
LA
Las Vegas
San Diego
Flagstaff
Albuquerque
Denver
Okla City
Dallas
New Orleans
Mobile
Honolulu
And many others...
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Tijuana
San Juan
Manila
Tokyo
Sasebo
Hong Kong
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And those experiences is why I have lived in rural NE FL for the last 30 years.
I never lost anything but time in any of those cities, and so I have no reason to return to any of them. I go to a city when I want to (rarely), or need to (occasionally) for various reasons, but I'd never chose to live in any of them.
Too many Rats in a box is never a good thing imo, and the bigger the city, the worse the Rats get...